Clinical application value of recombinant human growth hormone in the treatment of severe burns
10.3760/cma.j.issn.1008-6706.2014.10.022
- VernacularTitle:重组人生长激素在重度烧伤治疗中的临床应用价值
- Author:
Chunxin ZHANG
;
Yueping ZHOU
;
Qinzhi LIU
- Publication Type:Journal Article
- Keywords:
Human growth hormone;
Burns
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(10):1489-1490,1491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of recombinant human growth hormone ( rhGH) in the treatment of severe burns .Methods 36 patients with severe burns were selected and randomly divided into the observation group and control group ,18 cases in each group .Both two groups used the same anti-infection therapy , nutritional support and surgical methods .The observation group received rhGH subcutaneous injection therapy , the control group used the same amount of daily injections of 0.9%sodium chloride.The levels of tumor necrosis factor-α( TNF-α) and interleukin 6 ( IL-6 ) , wound healing time , hospitalization time and other indicators were compared between the two groups.Results 7d,14d after treatment,the TNF-αand IL-6 levels of the two groups were (18.4 ± 3.3)ng/L vs (24.9 ±7.3)ng/L,(133.2 ±66.9)ng/L vs (271.4 ±88.9)ng/L,(15.4 ±3.2)ng/L vs (25.4 ± 4.9)ng/L,(90.9 ±20.8) ng/L vs (200.7 ±62.2) ng/L,the differences were significant between the two groups (t=3.74,4.75,4.02,4.69,all P<0.05).The healing time and hospital stay in the observation group were signifi-cantly shorter than those of the control group (t=3.75,3.86,4.75,4.64,all P<0.05).Conclusion rhGH therapy can significantly improve the wound healing of severe burn patients ,reduce hospitalization time,it has good clinical results.
