CELLULAR LOCALIZATION OF SUPPRESSOR OF CYTOKINE SIGNALING-3 IN ADULT RAT RETINA
- VernacularTitle:细胞因子信号转导抑制因子SOCS-3在成年大鼠视网膜内的定位分布
- Author:
Meng LIU
;
Jing ZHAO
;
Xianzhong SHI
;
Enhua YU
- Publication Type:Journal Article
- Keywords:
SOCS-3;
JAK-STAT;
Retina;
Rat
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the basic expression and cellular localization of SOCS-3 in normal rat retina. Methods Neuro-immunocytochemistry techniques were used. Results SOCS-3 positive cells were widely distributed in the ganglion cell layer (GCL) and inner nuclear layer (INL) in the retina. In the GCL, SOCS-3 immunoreactivity was mainly in the neuclei of the ganglion cells.Some of the SOCS-3 positive cells in INL were M?ller cells.Conclusion Basal expression of SOCS-3 is widely present in the neurons and glia in normal adult rat retina and mainly in the form of nuclear protein.
