A comparative study of calcipotriol betamethasone ointment for the treatment of psoriasis vulgaris
10.3969/j.issn.1671-8348.2014.15.010
- VernacularTitle:钙泊三醇倍他米松软膏外用治疗寻常性银屑病临床对照研究
- Author:
Xin HUANG
;
Bin WEI
;
Sheng FANG
;
Kun HUANG
;
Aijun CHEN
- Publication Type:Journal Article
- Keywords:
psoriasis vulgaris;
psoriasis area and severity index score;
compound calcipotriol;
betamethasone preparation
- From:
Chongqing Medicine
2014;(15):1851-1853,1856
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of calcipotriol betamethasone ointment for the treatment of pso‐riasis vulgaris in the stable stage of patient .Methods This was a randomized ,parallel controlled clinical trials ,in which 90 patients with psoriasis vulgaris were randomly divided into experimental group and controlled group .All of them received 4 weeks of thera‐py .We compared the efficacy and safety 1 ,2 ,4 week after treatment by calcipotriol betamethasone ointment .Results About the clinical efficacy ,according to the decrease in percentage of psoriasis area and severity index (PASI) were:23 patients in the experi‐mental group were effective(efficacy rate is 76 .67% ) ,14 patients in control group Ⅰ was effective(efficacy rate is 46 .67% ) ,15 pa‐tients in control group Ⅱ was effective(efficacy rate is 50% ) .The differention between experimental group and the two control groups was significant(P< 0 .05 ,P< 0 .01) .After 1 ,2 ,4 weeks of therapy ,the decrease in percentage of PASI of experimental group is higher than that in the control groups .The scores of the observed erythema ,infiltration ,scale were decreased ,and the total scores of PASI are also decreased 4 weeks after therapy .The decrease score of experimental group is higher than that of control group Ⅰ(P<0 .01) and control group Ⅱ(P<0 .01) .The side effects of the experimental group are mild such as itching ,folliculi‐tis ,erythema ,and the laboratory examinations had no abnormal changes .Conclusion Calcipotriol betamethasone ointment was more effective to treat the stable stage psoriasis vulgaris patients compared with single use of halometasone or calcipotriol .It takes effect quickly ,and could be more feasible and safe .
