Panax notoginseng saponin liposomes:Characterization of pharmaceutics and pharmacokinetics on pulmonary instillation in rats
- VernacularTitle:三七总皂苷脂质体的药剂学性质及大鼠肺部给药药动学研究
- Author:
Yang SHEN
;
Xiaoling FANG
- Publication Type:Journal Article
- Keywords:
Panax notoginseng saponin (PNS) liposomes;
entrapping efficiency;
vesicle size;
stability;
pharmacokinetics
- From:
Chinese Traditional and Herbal Drugs
1994;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To prepare Panax notoginseng saponin (PNS) liposomes and investigate their characterization of pharmaceutics and pulmonary pharmacokinetics in rats. Methods The film-disperion method was used to prepare PNS liposomes by investigating its form, vesicle size, entrapping efficiency and stability. The study of pulmonary pharmacokinetics in rats was carried out by pulmonary instillation. Results The entrapment of PNS liposomes was 78.50%. The mean vesicle size was 1.5 ?m with uniform externality. The drug leakage from PNS liposomes was slow. Low temperature was required for its storage. The pulmonary pharmacokinetics parameters were as follows: T 1/2 ?=7.00 h, T 1/2 ?=27.72 h, AUC= 2 218.9 ?g?h/mL, the absolute bioavailability was 70.14%. Conclusion PNS liposomes with high entrapment and stability can prolong its circulation in blood and improve the PNS bioavailability via lung approach.
