Protection of Shexiang Antithrombosis Pill on experimental cerebral ischemia in rats
- VernacularTitle:麝香抗栓丸对大鼠实验性脑缺血的保护作用
- Author:
Hongmei ZHAO
;
Xiaofeng YU
;
Shaochun QU
;
Huali XU
;
Dayun SUI
- Publication Type:Journal Article
- Keywords:
Shexiang Antithrombosis Pill (SATP);
cerebral ischemia;
Ca2+;
MDA;
SOD;
LA
- From:
Chinese Traditional and Herbal Drugs
1994;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To observe the protective effect of Shexiang Antithrombosis Pill (SATP) on experimental cerebral ischemia in rats. Methods In cerebral ischemia model induced by bilateral common carotid artery clamping and controlled hemorrhage to a mean arterial pressure of 6.7 kPa (50 mmHg), cerebral water content, SOD activity, MDA, Ca 2+ , and LA contents were measured and the ischemic tissue pathology was observed. Results SATP can decrease cerebral water content, lessen pathological change, increase SOD activity and decrease MDA, Ca 2+ , and LA contents. Effect of water pill is better than that of honey pill. Conclusion SATP can protect the cerebral tissue from ischemia injury by suppressing lipid peroxidation. This effect may be related to increasing antioxidase activity and decreasing acidosis of LA and overload of calcium in cell.
