Effects of house dust mite injected in neonate rats on airway inflammation and TH subset in later life
- VernacularTitle:新生大鼠注射尘螨对其发育后期气道炎症作用的研究
- Author:
Jihong DAI
- Publication Type:Journal Article
- Keywords:
Asthma;
Animal model;
TH subset;
Mite
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study whether early exposure to house dust mite will aggravate airway inflammation as well as the onset of asthma and to explore the relevant mechanism.Methods:Neonate Wistar rats were injected with HDM subcutaneously instantly after birth.After the four times management,they were established as models of asthma with OVA,and bronchoalveolus was lavaged to count percentage of eosinophils.And levels of IL-4,IFN-? and serum OVA-IgE were also detected.Results:In HDM group,the percentage of EOS,level of serum OVA-IgE and level of IL-4 were (37.07?1.10) %,(0.20?0.023) and (78.96?12.18) pg/ml,respectively,the highest among the three groups,otherwise level of IFN-?,the lowest,(93.78?2.10)pg/ml.Conclusion:Early exposure to house dust mite after birth could aggravate the level of airway inflammation in later life and increase the level of IgE,which is related with T H1/T H2 imbalance.
