Effect of liposome-c-raf-1 antisense oligodeoxynucleotides on human ovarian carcinoma transplanted subcutaneously in nude mice
- VernacularTitle:脂质体-c-raf-1反义寡核苷酸治疗人卵巢癌裸鼠皮下移植瘤
- Author:
Yongzhong WU
- Publication Type:Journal Article
- Keywords:
Antisense oligodeoxynucleotides;
c-raf-1gene;
Ovarian epithelial carcinoma;
Tumor transplanted subcutaneously in nude mice
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Objective:To explore the effect of c-raf-1 antisense oligodeoxynucleotides (ASODN) treatment in the human ovarian epithelial cancer transplanted subcutaneously in nude mice.Methods:The models of human ovarian epithelial cancer transplanted subcutaneously were established in 15 nude mice,then divided randomly into 3 groups and different treatment were given respectively (control group,senseexperimental group and antisense experimental group).The weight of nude mice and tumor volume were observed,the tumor growth inhibitory rate and the tumor response rate calculated,too.Results:The growth inhibitory rate in sense experimental group and antisense experimental group were 6.8% and 68.1%,respectively,the tumor response rate of antisense experimental group was 16.7%.There was no statistical difference in nude mice weight among the 3 groups.Conclusion:The results suggest that there is a positive value in the human ovarian epithelial cancer transplanted subcutaneously in nude mice treated by c-raf-1 antisense oligodeoxynucleotides,which will be an important gene therapeutic strategy for the ovarian epithelial carcinoma in the future.
