Induction of immune responses against rotavirus by intramuscular and intranasal immunization with rotavirus DNA vaccine
- VernacularTitle:轮状病毒DNA疫苗经不同途径接种诱导体内免疫应答研究
- Author:
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
Rotavirus;
DNA vaccine;
Mucosal immunization
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To search for the efficient immune routes for rotavirus DNA vaccine by evaluating efficacy in inducing immune responses to rotavirus.Methods:In this study BALB/c mice were immunized by intramuscular and intranasal routes with rotavirus DNA vaccine,pcDNA 1/VP7,then rotavirus specific systemic immunity was measured.Results:Serum rotavirus specific IgG but not IgA titers of mice immunized by both routes were significantly higher than that of the unimmunized controls.Conclusion:Both intramuscular and intranasal routes are candidates for rotavirus DNA vaccine.
