Exploration of clinical diagnostic value of measuring sulfate glycosaminoglycan segment and antibody to tuberculosis in patients with hydrothorax
- VernacularTitle:硫酸氨基葡糖多聚糖片段与结核抗体检测对胸腔积液诊断价值的探讨
- Author:
Minchao LI
- Publication Type:Journal Article
- Keywords:
Sulfate glycosaminoglycan segment;
Antibody to tuberculosis;
Tuberculous pleuritis;
Malignant pleural effusion
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of detection of sulfated glycosaminoglycan(GAG) segment and IgG antibody to tuberculosis(TB-IgG) to diagnose tuberculous pleuritis and malignant pleural effusion.Methods:Using the lung tumor antigen(LTA) diagnostic kit and tuberculosis antibody colloidal gold diagnostic kit to detecte the GAG and TB-IgG of serum and pleural fluid separately of 357 patients suffering from hydrothorax.We proceeded a retrospective study and then had statistical evidence.Results:The positive rate and specificity of GAG of pleural effusion of lung cancer patients were 80.3%(106/132),88.4%,and that of serum were 54.5%(72/132),90.2%.The positive rate and specificity of TB-IgG of pleural effusion of tuberculous pleuritis were 66.2%(102/154),86.2%,and that of serum were 33.8%(52/154),83.7%.The specificity of GAG,combined with TB-IgG by measuring the pleural fluid of tuberculous pleuritis and malignant pleural effusion would increase to 97.0% and 98.2% separately.Conclusion:Detection of GAG and TB-IgG of pleural fluid is helpul for diagnosis of tuberculous pleuritis and malignant pleural effusion.GAG combined with TB-IgG can act as differential diagnosis marker of tuberculous pleuritis and malignant pleural effusion for its higher specificity.
