Establishment of Female Adult Rat Models with Acute Stress Reproductive- endocrine Disorder
- VernacularTitle:急性应激性雌性大鼠生殖内分泌紊乱模型的建立
- Author:
Xiaoyuan LIAN
;
Yan DING
;
Qi CHEN
;
Juntian ZHANG
- Publication Type:Journal Article
- Keywords:
Acute stress;
Estradiol;
Progesterone;
Corticosterone;
Reproductive- endocrine disorder
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of acute stress on reproductive- endocrine function in female adult rats. Methods Acute immobilization stress was used to challenge the female adult rats and then the serum levels of progesterone (P), estradiol (E2) and corticosterone were measured 2 h after the stress.Results Acute stress significantly reduced E2 levels in each period of sexual cycle and increased the levels of P and corticosterone in the stressed rats.In addition, the ratio of estradiol and progesterone was disordered in stressed rats.Conclusion Acute stress can cause the disorder of estradiol and progesterone.Since stress is a major factor contributing to reproductive- endocrine disorder, this model will be useful for the research and development of drugs for reproductive- endocrine disorder.
