Effect Of Salidroside on Apoptosis of Rat Hepatic Stellate Cells Stimulated by Acetaldehyde
- VernacularTitle:红景天苷对乙醛刺激的大鼠肝星状细胞凋亡的影响
- Author:
Xianfei ZHONG
;
Mingde JIANG
;
Hongde MA
;
Weizheng ZENG
- Publication Type:Journal Article
- Keywords:
Salidroside;
Hepatic stellate cells(HSCs);
Acetaldehyde;
Apoptosis;
c- Jun N- terminal kinase( JNK)
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Salidroside in inducing apoptosis of rat hepatic stellate cells (HSC) stimulated by acetaldehyde and to observe the changes of c- Jnk N- terminal kinase (JNK) activity.Methods HSC stimulated by acetaldehyde were cultured in vitro and were treated with different concentrations of Salidroside.Apoptotic rate was analyzed by flow cytometry and the activity of phosphorylating JNK was measured by Western blot method.Results Salidroside in different concentrations (1.0,1.5,2.0 mg/mL) suppressed the activity of JNK in a dose- effect manner.Average light density was 35.8? 3.4,24.9? 2.7 and 3.4? 0.9 in Salidroside groups, which differed from that in acetaldehyde group( 48.6? 4.8; P
