Influence of Different Excipients on the Stability of Baicalin Solution
- VernacularTitle:不同赋形剂对黄芩苷溶液稳定性的影响
- Author:
Ting ZHANG
;
Tingting ZHU
- Publication Type:Journal Article
- Keywords:
Baicalin;
Excipients;
Stability;
HPCL
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of different excipients on the stability of baicalin solution.Methods The thermostatic accelerated test was used to observe the effect of solubilizing agent (Meglumine and Glucose), solubilizer (Pluronic F- 68) and stabilizer (HP- ? - CD) on baicalin stability and the concentration of baicalin was determined by HPLC. Results The valid period of baicalin solution with solubilizing agent added was shortened, and that with solubilizer and stabilizer added prolonged. Conclusion It is feasible to increase the stability of baicalin solution with Pluronic F- 68 or HP- ? - CD added.
