Effect of Weiyanxiao Granule on Experimental Gastric Ulcer
- VernacularTitle:胃炎消颗粒抗实验性胃溃疡的作用
- Author:
Qun DU
;
Rujun WANG
;
Tingyin SHAO
;
Yanli WU
;
Xiaolin LIU
- Publication Type:Journal Article
- Keywords:
WEIYANXIAO GRANULE/pharmacology;
WEIYANXIAO GRANULE/therapeutic effects;
GASTRIC ULCER/TCD therapy;
GASTRIC MUCOSA /injury;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the effect of Weiyanxiao Granule (WG) in counteracting experimental gastric ulcer,acute lesion of gastric mucosa and to investigate its anti-inflammation and analgesic actions.Acute gastric ulcer models induced by stress or indomethacin, chronic gastric ulcer models induced by acetic acid and models with acute lesion of gastric mucosa induced by hydrochloride-ethanol or 0.2 mol?L -1 sodium hydroxide were used to observe the effect of WG in counteracting experimental gastric ulcer and acute lesion of gastric mucosa. Anti-inflammation action of WG was observed on mouse models with auricular swelling induced by dimethylbenzene, rat models with pedal swelling induced by white egg and rat models with granuloma induced by embedding tampon. Hot plate method and body-torsion test were used to observe the analgesic action of WG. As compared with the control group, WG 12.3?g?kg -1 and 24.6?g?kg -1 could decrease the ulcer index in rats with acute gastric ulcer (P
