Study on preparation and in vitro release characteristics of Bitongning Patch
- VernacularTitle:痹痛宁贴剂的制备及体外释放、透皮吸收研究
- Author:
Jiyong LIU
;
Qing GU
;
Jinhong HU
;
Jingzhen TIAN
- Publication Type:Journal Article
- Keywords:
Bitongning Patch;
Scopolamine;
in vitro release;
percutaneous absorption;
HPCE
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To prepare Bitongning Patch(Flos Daturae, Moschus and Camphora, etc.) and study its in vitro release characteristics. METHODS: Bitongning Patch was prepared with high polymer hydrophilic material as matrix. The determination method of scopolamine was established by HPCE. The in vitro release was studied according to the requirement of Chinese Pharmacopoeia(2000) and the percutaneous absorption of Bitongning Patch was evaluated in use of the Franz diffusion cell. RESULTS: The release mechanism of Bitongning Patch in vitro coincided with Higuchi Equation. The release rate was 0.4698mg?cm -2?h -1/2. Scopolamine in Patch permeated in vitro at the speed of 0.067mg?cm -2?h -1 by zero-order kinetics. CONCLUSIONS: Bitongning Patch is a skeleton controlled TDDS whose permeation speed is limited by skin.
