Influence of gel vehicles on release in vitro and transdermal resorption of integerrimine
- VernacularTitle:不同基质对全缘千里光碱凝胶剂体外释放和透皮特性的影响
- Author:
Yuehong XU
;
Lianying XU
;
Dingguo CAI
;
Bao CHEN
;
Lan HE
- Publication Type:Journal Article
- Keywords:
integerrimine;
senecio faberic hemsl;
gel vehicles;
transdermal resorption;
release in vitro;
naked mouse
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The gel vehicle was optimized by release and transdermal resorption of integerrimine in vitro in order to design its anti-cancer transdermal drug delivery system. METHODS: The releasing rate was detected by dissolution Vilia-Chien diffusion cells, nude mouse skin were used as permeation barrier, the concentration of integerrimine in samples was measured by RP-HPLC. RESULTS: Integerrimine releases of three different vehicles conformed to Higuchi equation, the releasing rate of CMC-Na gel is faster than that of HPMC gel, and that of Carbopol gel is the slowest in three, and corresponded with zero kinetic equation. CONCLUSION: HPMC is an drug vehicle of choice.
