THE EXPRESSION OF AGRIN IN RAT CORTEX DURING THE POSTNATAL TIME
- VernacularTitle:蛋白聚糖在发育期大鼠大脑皮质的表达
- Author:
Weixi WANG
;
Bingfang LIU
;
Erjing GAO
;
Qunyua XU
- Publication Type:Journal Article
- Keywords:
Agrin;
Development of the brain;
Immunohistochemistry;
Rat
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of heparan sulfate proteoglycan(HSPG)-Agrin in rat cortex of postnatal time in order to understand the relation between the development of cortex and agrin. Methods We performed immunohistochemical analysis of agrin expression in the postnatal rat cortex with agrin-specific polyclonal antibody. Results Agrin expression was shown to have significant differences in the different periods of postnatal time.It increased from postnatal 2 day(p2) to postnatal day 6(p6),then declined steadily after p6 and reached adult levels by 4w.In this periold of time,agrin has different expression peak following to the cortex layer development.Conclusion:Agrin is related to the development of cortex and may play an important role in the developing of central nervous system.;
