Significance of metabonomics in modern research of Chinese materia medica
- VernacularTitle:代谢物组学在中药现代研究中的意义
- Author:
Changxiao LIU
- Publication Type:Journal Article
- Keywords:
metabonomics;
research and development of new drugs;
drug screening;
drug safety;
Chinese materia medica
- From:
Chinese Traditional and Herbal Drugs
1994;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
Metabonomics is a new branch of "-omics" science in post-gene time. The physiological and biochemical situation can be directly understood by its "metabolome profile" as a whole in metabonomics. Therefore it can provide a lot of information that differs from those came out of other "-omics". Metabonomics has been used to evaluate the test animal models and xenobiotics each producing a distinctive series of metabolic perturbations that are characteristic of the type of action mechanism, target organ of toxicity, and tissue damage. In research and development of new drugs, metabonomics is hopeful to be necessary part. Applying metabonomics involves metabolic databases for the use in discovery of new biomarkers, in screening of new drugs, in drug safety testing, and in action mechanism research. Metabonomics is also hopeful for modern research of Chinese materia medica.
