Increased expression of extracellular matrix metalloproteinase induced in rheumatoid synovium
- VernacularTitle:类风湿关节炎滑膜组织中细胞外基质金属蛋白酶诱导因子的研究
- Author:
Qunhua JIN
;
Houshan LU
;
Zhankun CHEN
;
Dongfang JIAN
;
Yiehua WANG
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Synovial membrane;
Extracellular matrix metalloproteinase induced
- From:
Chinese Journal of Rheumatology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of extracellular matrix metalloproteinase induced (EMMPRIN) in the synovial membrane of patients with rheumatoid arthritis (RA).Methods Immunohistochemistry were performed to characterize the EMMPRIN-expressing cells at sites of joint destruction derived from RA and osteoarthritis (OA) patients.Reverse trancription polymerase chain reaction (RT-PCR) was performed to study the existence of EMMPRIN in synovial membrane samples.And it was followed by computer assisted image analysis in order to detect the A values of their experession.Results EMMPRIN immunoreactivity was more intense in RA than in OA synovial membrane (P
