Change of immune function in children patients with Henoch-Schonlein purpura and its clinical significance
10.3969/j.issn.1673-4130.2014.11.017
- VernacularTitle:初发过敏性紫癜患儿免疫功能变化及其临床意义
- Author:
Shan LIN
;
Shiguang LIN
;
Ruiguan GUO
;
Ruxiang WU
;
Jing LI
;
Mingqing HUANG
- Publication Type:Journal Article
- Keywords:
Henoch-Schonlein purpura;
child;
lymphocyte subsets;
immunioglobin;
complement
- From:
International Journal of Laboratory Medicine
2014;(11):1417-1418,1421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the change of cellular immune and humoral immune function in children patients with Henoch-Schonlein purpura(HSP)and to investigate its clinical significance.Methods The expression levels of T lymphocyte CD3 + ,CD3 +CD4 + ,CD3 + CD8 + ,CD3 + CD4 + CD8 + ,B lymphocyte CD3 - CD19 + and NK lymphocyte CD3 - CD16 + CD56 + in periphetal blood of 156 patients with HSP was detected by flow cytometry.The level of immunioglobins(IgG,IgA,IgM)and complement(C3,C4)of serum were evaluated by nephelometry immunoassay.The level of immunioglobin IgE was measured by immunochemiluminometric assays and compared with 25 healthy controls.Results Compared with control group,the ratio of CD4 +/CD8 + and the contents of CD3 + ,CD4 + cells in HSP patients were decreased significantly(P <0.01),while the content of CD19 + was significantly increased (P <0.01).The content of CD16 + CD56 + was decreased(P <0.05 ),while the content of CD3 + CD4 + CD8 + was increased(P <0.05),the content of CD8 + had no obvious change(P >0.01).The level of IgA and IgE were increased significantly(P <0.01).The level of IgG and C3 were increased (P <0.05),The level of IgM and C4 had no obvious change(P >0.05).Conclusion The cellular immune and humoral immune function in children with HSP are in disorder.To detect lymphocyte subsets,immunioglobin and com-plement will be of important significance to understand the immune function from the perspective of the cellular immune and humor-al immune to explore the pathogenic mechanisms and to assist diagnosis and patient′s prognosis.
