Effect of polydatin on endothelial function in aorta vascular strips of healthy rabbits treated with ADMA
- VernacularTitle:虎杖苷对ADMA作用的正常兔主动脉血管条内皮功能的影响(英文)
- Author:
Jian QIN
;
Yunzhen CHEN
;
Qixin ZHOU
;
Ruofei SHI
;
Qingsong JIANG
;
Qin LOU
- Publication Type:Journal Article
- Keywords:
polydatin (PD);
asymmetric dimethylarginine (ADMA);
nitric oxide synthase;
phenyl- ephrine (PE)
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectTo study the effect of polydatin (PD) and asymmetric dimethylarginine (ADMA) on the endothelial function in aorta vascular strips of healthy rabbits and the interaction between PD and ADMA. MethodsDose-response curves of phenylephrine (PE) on the aortic strips with or without ADMA and/or PD. E max and Kd from PE were obtained and compared. ResultsNormal aortic strips could not respond to ADMA. Pretreatment with either PD or ADMA had no effect on the contractive response of aortic strips to PE. But PD could significantly weaken the contractive response of aortic strips pretreated with ADMA caused by PE in a dose-dependent manner, increase Kd and decrease E max of PE. ConclusionEither ADMA or PD alone does not influence the normal aortic strip contractive functions, the PE affinity to ?-receptor, and E max. But PD could noncompetitively antagonize the contractive reaction of aortic strips to PE in the presence of ADMA.
