Inhibition of Anti-EB Virus Liquor on EB virus antigen expression and its cytotoxicity
- VernacularTitle:抗EB病毒口服液对EB病毒抗原表达的抑制作用及其细胞毒作用
- Author:
Zongchao LIU
;
Shaowen JIAN
;
Huazhong LI
;
Jingcai OU
;
Bingfen XIE
;
Duan LI
;
Gongkan FENG
- Publication Type:Journal Article
- Keywords:
Anti-EB Virus Liquor (AEVL);
EB virus;
antigen expression;
nasopharyngeal carcinoma
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the inhibitory effect of Anti-EB Virus Liquor (AEVL) on EB (Epstein-Barr) virus antigen expression and its cytotoxicity. Methods The effect of AEVL on Raji cell early antigen (EA) expression and B 95-8 cell virus capsid antigen (VCA) expression was assayed by indirect fluorescent technique; the cytotoxicity on nasopharyngeal carcinoma CNE 2 cells was determined by MTT method. Results At the non-toxic concentration, AEVL had markedly inhibitory effect on Raji cell EB-virus, IC 50 was 0.667 mg/mL and showed powerfully inhibitory effect on B 95-8 cell EB-virus VCA expression, IC 50 was 0.89 mg/mL; and it had strongly inhibitory effect on B 95-8 cell EB virus VCA expression stimulated by sodium n-butyric acid, IC 50 was 1.4 mg/mL. The IC 50 of AEVL on human nasopharyngeal carcinoma CNE 2 cell was 7.57 mg/mL. Conclusion AEVL could inhibit EB virus antigen expression and have cytotoxicity on nasopharyngel carcinoma cells at high concentration.
