Expression characteristics of chemotherapeutic related genes in non-small cell lung cancer
10.3969/j.issn.1671-8348.2014.11.002
- VernacularTitle:非小细胞肺癌化疗相关基因标志物表达特征分析
- Author:
Shiheng ZHANG
;
Zheng LI
;
Yu PENG
;
Yang PENG
;
Yuxin YANG
;
Chongyi LI
;
He XIAO
;
Dong WANG
- Publication Type:Journal Article
- Keywords:
carcinoma,non-small cell lung;
antineoplastic combined chemotherapy protocols;
biological markers;
apurinic endo-nuclease
- From:
Chongqing Medicine
2014;(11):1284-1286,1289
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression characteristics of chemotherapeutic related genes (ERCC1 ,BRCA1 ,APE1 , RRM1 ,TUBB3 and TS) in non-small cell lung cancer(NSCLC) and their associations with the pathological types to provide the ex-perimental evidences for clinical individual chemotherapy .Methods The immunohistochemical SP method was used to determine the expression of ERCC1 ,BRCA1 ,APE1 ,RRM1 ,TUBB3 and TS genes in 733 patients with NSCLC .Chi-square test was performed to analyze the gene expression characteristics among different pathological types .Spearman relationship was conducted to evaluate the associations among the six genes and different pathological types .Results The expression of BRCA1 ,TUBB3 and TS had sta-tistical differences among three pathological types (P<0 .01);and these three genes showed a relationship with the pathological type (r=0 .107 ,-0 .229 and 0 .168 ,respectively ,P<0 .01) .ERCC1 vs .BRCA1 ,ERCC1 vs .APE1 and APE1 vs .RRM1 showed the pos-itive correlation(r=0 .214 ,0 .316 and 0 .222 ,respectively ,P<0 .01) .Conclusion The chemotherapeutic related gene expressions of NSCLC are related with the clinical pathological types .And the expressions of multiple markers are associated with each other .The combined detection of the chemotherapeutic related markers and the pathological types would be helpful to the decision making of individual chemotherapy in clinic .
