Study on growth inhibitory effect of chemotherapeutic drugs on the pancreatic cancer cell line-Aspc-1 and Bxpc-3
- VernacularTitle:化疗药物对胰腺癌细胞株Aspc-1和Bxpc-3生长抑制作用的研究
- Author:
Junjie ZOU
;
Yaoliang PENG
;
Chuncai DAI
- Publication Type:Journal Article
- Keywords:
Pancreatic carcinoma;
MTT;
Chemotherapy
- From:
Journal of Interventional Radiology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the growth inhibitory effect of chemotherapeutic drugs on the pancreatic cancer cell line Aspc-1 and Bxpc-3, and the relations to the varied concentration and exposere time of chemotherapeutic drugs administrated in single or in combination. Methods Four chemotherapeutic drugs included 5-fluorouracil (5-FU), epirubicin (E-ADM), mitomycin(MMC) or cisplatin (DDP) administrating in single or in combination and using varied concentrations(d1、d2、d3 and d4) and exposure times(24、28 and 72 hours); and then the growth inhibitory effect on the two cell lines. resulted from these drugs were assayed by MTT colorimetry and analysed by “ t ” test. Results The growth inhibitory rate of two cell lines was increased, with the increment of drug concentration and/or the prolongation of exposure time ( P
