The relationship between amino-acid motif of HLA-DR?1*04(?chain) and the susceptibility to rheumatoid arthritis
- VernacularTitle:HLA-DR?1*04亚型的氨基酸序列与类风湿关节炎易感相关性分析
- Author:
Yin SU
;
Zhanguo LI
;
Rulin JIA
;
Weiyi ZHENG
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
HLA-DR4 antigens;
Amino acid sequence
- From:
Chinese Journal of Rheumatology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the susceptibility to rheumatoid arthritis (RA) with HLA- DR?1*04 subtypes.Methods One hundred and thirty-six RA patients and 79 patients with other rheumatic diseases were recruited in this study.HLA typing was performed using high-resolution PCR-SSP DNA techniques.The clinical features and serologic markers between different motifs were analyzed.Results Compared with other rheumatic diseases,the frequency of HLA-DR?1*04 alleles in RA patients was significantly increased(33.8% vs 12.7%)(OR=3.52,95%CI=1.43~5.43,P
