The relationship between MMP-9 serum level and disease activity in patients with systemic lupus erythematosus
- VernacularTitle:血清基质金属蛋白酶-9检测与系统性红斑狼疮活动性的关系
- Author:
Yang LIU
;
Min ZHENG
;
Wenhao YIN
;
Zhang BAO
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Gelatinase B;
Enzyme-linked immunosorbent assay
- From:
Chinese Journal of Rheumatology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum level of MMP-9(matrix metalloproteinase-9) and the disease activity of systemic lupus erythematosus(SLE).Methods Serum level of MMP-9 of 30 controls and 36 SLE patients were measured by Enzyme Linked Immuno Sorbent Assay.Results Significantly decreased serum level of MMP-9 was found in SLE patients as compared to that in healthy controls(108?113) ng/ml vs (352?155) ng/ml (P0.05).Conclusion The present data suggests that MMP-9 may be involved in the pathogenesis of SLE,and serum MMP-9 level may be a marker of disease activity,renal damage,disease progression and amelioration in SLE.
