The influence of extract of schisandra chinensis and paeonia veitchii on the level of cytokines in serum of asthmatic rats

VernacularTitle:五味子和芍药提取物对哮喘模型大鼠血清细胞因子水平的影响
Author: Xia CHEN ; Jun TANG ; Jing FENG
Publication Type:Journal Article
Keywords: schisandra chinensis; paeonia veitchii; cytokine
From: Chongqing Medicine 2013;(29):3486-3487,3490
CountryChina
Language:Chinese
Abstract: Objective To investigate the influence of extract of schisandra chinensis and paeonia veitchii on level of cytokines in asthmatic rats .Methods SD rats were randomly divided into three groups :Chinese medicine-treated ,untreated asthma ,physiologi-cal saline control groups .The tracheal pathology and symptom of different groups were observed ,then cytokine expressions in ser-um were detected with enzyme-linked immunosorbent assay (ELISA ) .Results Chinese herb extract obviously improved tracheal pathology and airway symptoms .The levels of IL-4 ,IL-6、IL-13 in serum of Chinese medicine-treated and untreated asthma groups were significantly increased ,while the IFN-γ expression was reduced .But after treatment of Chinese herb extract ,compared with untreated asthma group the IFN-γexpression was significantly increased in Chinese medicine-treated group .Conclusion The effect of extract of schisandra chinensis and paeonia veitchii could reduce airway inflammation of asthma rats may by significantly in-creased IFN-γexpression .