Analysis about the relationship between thyroid hormone and leptin in Graves' disease of woman
- VernacularTitle:女性Grave’s病患者甲状腺激素与瘦素关系探讨
- Author:
Dongfang LIU
- Publication Type:Journal Article
- Keywords:
Hyperthyroidism;
Thyroid hormone;
Leptin
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship of hyperthyroidism and the level of leptin and the role of thyroid hormone in leptin secretion.Methods:FT3,FT4,TSH,serum leptin and body weight were measured in 30 female Graves' patients and 30 female controls;the percentage of body fat and leptin were calculated,the changes in various index after 6-month treatment with methimazole were observed,the relationship between thyroid hormone and leptin,percentage of leptin analyzed,and multiple regressive analysis was made on these factors.Results:The BMI,percentage of body fat and leptin level were lower than controls,however,percentage of leptin was higher than controls.The leptin level elevated insignificantly but percentage of leptin decreased significantly after 6 months treatment with methimazole.Percentage of leptin showed positive correlation with FT3,FT4 and BMI percentage of body fat.Conclusion:The percentage of leptin is higher in female thyroid hyperfunction patients than controls and thyroid hormone increases the secretion of leptin even on the condition of thyroid hyperfunction.
