Experimental model of chronic heart failure resulting from pressure overload in juvenile rats and its pathophysiological changes
- VernacularTitle:慢性压力负荷性心衰幼鼠实验模型建立及其病理生理探讨
- Author:
Kai ZHOU
- Publication Type:Journal Article
- Keywords:
Chronic heart failure;
Ventricular remodeling;
Cardiomyocyte apoptosis;
Oxidative stress;
Juvenile rat;
Animal model
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To make animal model of chronic heart failure(CHF)resulting from pressure overload in juvenile rats,and discuss its pathophysiology.Methods:The animal model of CHF was established by constriction of abdominal aorta.After four weeks of operation,the high frequency ultrasonography,the hemodynamic study,the pathologic analysis of hearts were undergone,the cardiac myocyte apoptosis,and serum contents of lipid peroxidation(LPO) and superoxide dismutase(SOD) were investigated.Results:Compared with the sham-operated group,inner diameter,wall thickness of left ventricule,LVRW,RVRW,SBP,DBP,LVSP,LVEDP,AI,LPO increased significantly( P
