Experimental study on the pharmacokinetics and ototoxicity of amikacin with therapeutic doses in neonatal guinea pig
- VernacularTitle:治疗剂量阿米卡星在新生豚鼠药代动力学及耳毒性研究
- Author:
Hongmei XU
- Publication Type:Journal Article
- Keywords:
Amikacin;
Guinea pig;
Pharmacokinetics;
Ototoxicity
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To clarify the possibility of higher sensitivity to ototoxicity of aminoglycosides in neonatal animal.Methods:The difference in ototoxicity was studied by scanning electron-microscopy and microscopy between neonatal and adult groups of 36 guinea pigs administrated with therapeutic doses of amikacin.Pharmacokinetics was investigated in 10 guinea pigs in each group by TDx system.Results:(1)The pharmacokinetics were compatible with the model of two compartment in all age groups.There was no significant difference in the peak level and peak time.Compared with adult group, the plasma clearance was lower(0.0044?0.0011 and 0.0088?0.0014 L/min. kg, P
