Effects of Diammonium Glycyrrhizinate on Arrhythmia Induced by Myocardial Ischemia-reperfusion in Rats
- VernacularTitle:甘草酸二铵对大鼠心肌缺血再灌注心律失常的影响
- Author:
Jiangang JIANG
;
Jiliang WU
;
Jinhe CHEN
;
Daowen WANG
- Publication Type:Journal Article
- Keywords:
Diammonium glycyrrhizinate;
Myocardial reperfusion injury;
Arrhythmia;
Lipid peroxidation
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of diammonium glycyrrhizinate (DG) on arrhythmia induced by acute myocardial ischemia-reperfusion injury.Methods Electrocardiogram of lead Ⅱwas examined on the myocardial ischemia-reperfusion model,which was induced by the 10 min of ligation of left descending coronary artery and then 30 min of reperfusion in rats.Myocardial malondialdehyde (MDA) content,superoxide dismutase (SOD) activity and adenosine triphosphatase (ATPase),and serum lactate dehydrogenase (LDH) and creatine phosphokinase (CK) levels were measured.Results As compared with the model,DG significantly reduced the incidence of ventricular arrhythmia and its score (P
