Relationship of Anti-inflammatory Effects of Tetramethylprazine with Histamine and 5-Hydroxytryptamine
- VernacularTitle:川芎嗪的抗炎作用与组胺、5-羟色胺的关系
- Author:
Zhiyun FAN
;
Hong LUO
;
Yulan LIU
;
Yongyan WEI
- Publication Type:Journal Article
- Keywords:
Tetramethylprazine;
Anti-inflammatory effects;
Histamine;
5-hydroxytryptamine
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of the anti-inflammatory effects of tetramethylprazine with histamine and 5-hydroxytryptaphane(5-HT).Methods The contents of histamine and 5-HT in the inflammatory exudate of rats were determined by fluorescence technique.The effect of tetramethylprazine on histamine and 5-HT were analyzed by in-vitro ileum contraction test in guinea pigs.Results Tetramethylprazine significantly decreased the contents of histamine and 5-HT in the inflammatory exudate,and markedly antagonized the contraction of isolated ileum induced by histamine and 5-HT.Conclusion The anti-inflammatory mechanisms of tetramethylprazine may be related to the inhibition of the synthesis or release of histamine and 5-HT,as well as its direct antagonism.
