Studies on Preparation of Ginkgolic Acids Gel and Its Antibacterial Test
- VernacularTitle:银杏酸凝胶剂的制备及抑菌试验研究
- Author:
Xiaoli ZHANG
;
Zhen OUYANG
;
Xiaoming YANG
;
Jun CHEN
- Publication Type:Journal Article
- Keywords:
Ginkgolic acids;
Gel;
HPLC;
Antibacterial test
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare the preparation of ginkgolic acids gel and to study its antibacterial activity in vitro.Methods The gel was prepared with ginkgolic acids as main component and with Carbopol 940 as base material.The content of ginkgolic acids in the gel was determined by high performance liquid chromatography and the minimum inhibitory concentration (MIC) of the gel against staphylocococus aureus and propionibacteria was measured in vitro by means of liquid-doubling dilution.Results The ginkgolic acids gel has inhibitory effects on staphylocococus aureus and propionibacteria to various extents.And the MIC was 31.756 mg?mL-1 for staphylocococus aureus and 0.992 mg?mL-1 for propionibacteria.Conclusion The preparation of the gel is feasiblye and the the properties of the gel were stable.The ginkgolic acids gel possesses good antibacterial effects on staphylocococus aureus and propionibacteria.
