Experimental Studies on Modified Zhuling Decoction in Treating Primary Mesangial Proliferative Glomerulonephritis
- VernacularTitle:加味猪苓汤治疗原发性系膜增殖性肾炎的实验研究
- Author:
Shijian QUAN
;
Zhengmu LI
;
Guiquan XIE
;
Lijun ZHANG
- Publication Type:Journal Article
- Keywords:
GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE/TCD therapy;
CYTOKINES;
RNA, MESSAGER;
MODIFIED ZHULING DECOCTION/therapeutic use;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To explore the therapeutic mechanism of modified Zhuling Decoction (MZD) in treating primary mesangial proliferative glomerulonephritis (PMPG). [Methods] Rat models of PMPG were induced by rabbit type antibody of rat thymocyte (Thy-1). Forty rats were randomized into four groups: A (normal control), B (model), C (treated with heparin) and D (treated with MZD). Biochemical indexes in blood, activities of cytokines such as interleukin-1? (IL-1?), tumor necrosis factor ? (TNF-?) and interleukin-6 (IL-6) and mRNA expression of IL-6 were observed. [Results] As compared with group A, serum contents of IL-1?, TNF-? and IL-6 were increased and mRNA expression of IL-6 was promoted in group B (P
