Effect of Intestine-Dredging and Qi-Benefiting Method in the Management of Systemic Inflammatory Response and Multiple Organ Dysfunction in Rats
- VernacularTitle:通腑益气法对多器官功能障碍大鼠全身炎症反应的调控
- Author:
Shuhe WENG
;
Junxiong LIANG
;
Aimin DING
;
Sihui WU
- Publication Type:Journal Article
- Keywords:
MULTIPLE ORGAN FAILURE/TCD therapy;
TUMOR NECROSIS FACTOR/blood;
NITRIC OXIDE/blood;
DISEASE MODELS, ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To discuss the effect of intestine-dredging and Qi-benefiting method and its corresponding prescription in managing systemic inflammatory response and preventing multiple organ dysfunction syndrome (MODS). [Methods] Eighty. SD rats were randomized to control, model, low-dosage (LD) and high-dosage (HD) groups. One day before modeling, HD and LD groups were administered the preparation based on intestine-dredging and Qi-benefiting method by 60g/kg and 30 g/kg for 2 times, and control and model groups were given equal amounts of normal saline. On the 2nd day after the administration, 3 groups except the control group were modeled on the given reference. Twelve hours after modeling, the content of TNF-? and NO in serum was examined and histopathological examination of the main organs was conducted. [Results] Compared with the control group, the level of TNF-? and NO significantly increased (P
