Itraconazole application for prevention of fungal infection in patients receiving allogeneic hematopoietic stem cell transplants
10.3969/j.issn.1671-8348.2013.25.001
- VernacularTitle:伊曲康唑在异基因造血干细胞移植真菌感染预防中的应用
- Author:
Li PEI
;
Ling WEI
;
Dabing QIN
;
Xiaobo TIAN
;
Gang FU
;
Yan ZHU
;
Yong ZHANG
;
Jieping CHEN
- Publication Type:Journal Article
- Keywords:
fungal infection;
hematopoietic stem cell transplantation;
itraconazole
- From:
Chongqing Medicine
2013;(25):2953-2954,2958
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect of itraconazole in prevention of invasive fungal infections in allogeneic hema-topoietic stem cell transplantion .Methods In this retrospective study ,110 patients receiving allogeneic hematopoietic stem cell transplants were administed itraconazole or fluconazole for prevention of fungal infection .The occurrence and prognosis of invasive fungal infection ,and the side effect of both pyrroles were observed .Results Proven and probable invasive fungal infections occurred in 5 of 69 itraconazole recipients(7 .2% ) and in 8 of 41 fluconazole recipients(19 .5% ) during the first 180 days after transplanta-tion ,the difference had statistical significance(P<0 .05) .The fatality rate related to fungal infection had no statistical difference be-tween the two groups(2 .9% vs .7 .3% ) .The occurrence of itraconazole adverse reactions were more than fluconazole (26 .9% vs . 7 .0% ) ,and both itraconazole and fluconazole were well tolerated .Conclusion Itraconazole significantly reduces the incidence of inva-sive fungal infection in the patients receiving allogeneic hematopoietic stem cell transplants ,and it is a effective and safe prophylaxis .
