Effect of pressure in supercritical state on extraction and crystallization of andrographolide
- VernacularTitle:超临界状态下压力对穿心莲内酯萃取结晶的影响
- Author:
Wencheng ZHANG
;
Jian PAN
;
Kexun CHEN
;
Huiming XIE
- Publication Type:Journal Article
- Keywords:
andrographolide;
supercritical CO 2 fluid extraction;
crystallization
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To separate and purify andrographolide by supercritical CO 2 extraction and crystallization. Methods The method of systematic observation was used to investigate the crystal appearance, purity and mass of andrographolide by supercritical CO 2 extraction and crystallization, analyzing by scanning electron microscope (SEM) and HPLC. Results The higher the pressure, the smaller and shorter the crystal shape, and the purer the purity, the more the mass of andrographolide. Conclusion This technique is a innovation of traditional supercritical fluid extraction (SCFE) technique, which realizes highly effectual separation of andrographolide by supercritical CO 2 extraction and synchronous crystallization, developes a new technology to separate andrographolide and other active ingredients from Chinese traditional herbs.
