Clinical Features of Swyer-James Syndrome.
- Author:
Sun Hee CHOI
1
;
Do Kyun KIM
;
Seon Hee LEE
;
Young Yull KOH
Author Information
1. Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea. kohyy@plaza@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Swyer-James syndrome;
Hyperlucent lung
- MeSH:
Adenoviridae;
Bronchiectasis;
Bronchiolitis;
Bronchiolitis Obliterans;
Cough;
Emphysema;
Humans;
Lung;
Lung Diseases;
Lung, Hyperlucent*;
Medical Records;
Methacholine Chloride;
Mycoplasma pneumoniae;
Pneumonia;
Pneumonia, Mycoplasma;
Respiratory Sounds;
Respiratory Tract Infections;
Sputum;
Thorax
- From:Pediatric Allergy and Respiratory Disease
2006;16(3):233-242
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Swyer-James syndrome is an uncommon abnormality characterized radiographically by a hyperluncent lobe or lung and functionally by normal or reduced volume during inspiration and air trapping during expiration. The condition typically follows certain respiratory infections in infancy or early childhood. Thus, it is a postinfectious form of bronchiolitis obliterans. Most patients have chronic cough, sputum, and abnormal breathing sounds, and present with repeated pulmonary infections. The syndrome affects pulmonary functions and may cause anatomical changes such as bronchiectasis and emphysema. We reviewed cases of Swyer-James syndrome, in order to better understand the clinical manifestations and outcomes of the disease. METHODS: The diagnostic criteria were small or normal-sized unilateral hyperlucent lung with air-trapping during expiration based on chest X-ray or CT and history of severe lung infection. A total of 12 patients were found. Medical records, radiological studies, and other clinical test results were reviewed. RESULTS: Most of the patients had chronic respiratory symptoms and signs. All patients had pneumonia or bronchiolitis as initial insult. Microbial agents were determined in six patients, of whom three were adenovirus and the others, Mycoplasma pneumoniae. They had restrictive and obstructive patterns of pulmonary function with bronchial hyperresponsiveness for methacholine. Two patients underwent lobectomy for emphysema and bullous emphysema, respectively. CONCLUSION: In this study, Swyer-James syndrome is a severe chronic pulmonary disease, presenting with respiratory symptoms, and functional and anatomical changes including bronchiectasis and emphysema. Further rejearch is needed to investigate initial etiologic agents and pathogenesis; further research is also needed for the care of chronic respiratory problems.
