Effect of preoperative transcatheter arterial chemoembolization on proliferation of hepatocellular carcinoma cells
- VernacularTitle:术前经动脉化疗栓塞对肝癌细胞增殖的影响
- Author:
Enhua XIAO
;
Jinqing LI
;
Jiefu HUANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Transcatheter arterial chemoembolization;
Proliferation
- From:
Journal of Interventional Radiology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of preoperative transcatheter arterial chemoembolization on proliferation of hepatocellular carcinoma cells. Methods A total of 136 patients with hepatocellular(HCC) underwent liver resection and pathologic confirmation. One to five courses of TACE prior to liver resection were performed in 79 patients (TACE group); with one to four courses of chemotherapy alone were performed in 11 patients (Group A); one to five courses of chemotherapy combined with iodized oil were performed in 33 patients (Group B); one to three courses of chemotherapy combined with iodized oil and gelation sponge were performed in 23 patients (Group C); one to three courses of chemotherapy combined with iodized oil, ethanol and gelatin sponge were performed in 12 patients (Group D). The other 57 patients only received liver resection (non-TACE group). The expressions of Ki-67 and proliferating cell nuclear antgen(PCNA) protein were detected by immunohistochemical method. Results The Ki-67 and PCNA protein expressions were significantly lower in Groups C and D than those in the non-TACE group (P
