An experimental investigation on the concentration of selective infusion of urokinase in superacute cerebral embolism in dog
- VernacularTitle:超急性期脑栓塞动脉内灌注不同浓度尿激酶的实验研究
- Author:
Tianyun MA
;
Xiangwen MENG
;
Shiping YU
- Publication Type:Journal Article
- Keywords:
Cerebral embolism and thrombosis;
Thrombolytic therapy;
Urokinase;
Dog
- From:
Journal of Interventional Radiology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of thrombolysis of inta-arterial infusion of different concentrations of urokinase(UK) in dogs. Methods 25 healthy crossbreeding dogs were divided into five groups, with five dogs in each group. Every dog was injected with self-thrombus from carotis interna artery to embolize its distal part or branchers. Treatment with different concentrations of UK was initiated 2 hours after setting up the model of cerebral embolism by carotis interna artery. The dose of each group was: A(control group), 0.9% physiological sodium chloride solution; B,1 200U/ml UK; C,6 000U/mlUK; D, 12 000U/mlUK; E, 60 000U/mlUK. Angiography and CT scannings were performed before and after thrombolysis. Pathologic examination was performed 24 hours after embolism. Results The rate of recanalization of groups A,B were 0 but 100% for groups C,D and E, Judged by angiographies after thrombolysis, group C,D and E had significantly better reperfusion compared with group A,B(P
