Extraction of Volatile Oil of Rhizoma Zedoariae in Weishu Granules and Preparation of Its ?-cyclodextrin-inclusion complexes
- VernacularTitle:胃舒颗粒中莪术挥发油的提取及?-环糊精包合物的制备研究
- Author:
Wei HE
;
Zhufeng CONG
;
Yong LI
- Publication Type:Journal Article
- Keywords:
Weishu Granules;
Volatile oil of Rhizoma Zedoariae;
? - cyclodextrin;
Ultraviolet spectrophotometry;
Orthogonal test
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the conditions of process for extraction of volatile oil of Rhizoma Zedoariae (RZ) in Weishu Granules and preparation of its ? - cyclodextrin- inclusion complexes. Methods Orthogonal design was adopted. Extraction content of RZ volatile oil was used as the index for the optimizing of extraction process. The amount of inclusion complexes and efficient inclusion rate served as the indexes for the optimizing of inclusion process. Ultraviolet spectrophotometry was applied to detect the content of volatile oil. Results The optimal extraction conditions were: gringding the crude RZ into coarse grains, adding 12- fold water and distilling the mixture for 6 h; the optimal inclusion conditions were: ? - cyclodextrin and volatile oil were mixed in the proportion of 8 :1, 2- fold water was added into the mixture and the mixture was triturated for 60 min. The maximum UV spectrum absorbance of aethylis acetas liquor of valatile oil located at wavelength of 253nm. Conclusion Higher extraction rate of RZ volatile oil can be achieved by this technique; volatile oil is powdered and its stability increased after being included by ? - cyclodextrin.
