Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 protein in the implantation window phase of endometrium in ovulation normal women
- VernacularTitle:排卵正常妇女子宫内膜种植窗期基质金属蛋白酶-9及其抑制物-1的表达特点及作用
- Author:
Wenwu GUI
- Publication Type:Journal Article
- Keywords:
Endometrium;
Implantation window;
Matrix metalloproteinase-9;
Tissue inhibitor of metalloproteinase-1;
Embryo implantation
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Objective:To study the expression of matrix metalloproteinase-9 (MMP-9)/tissue inhibitor of metalloproteinase-1(TIMP-1) protein in the implantation window endometrium phase in ovulation normal women and the role of MMP-9/TIMP-1 on embryo implantation.Methods:SEM was used to determine “implantation window” of the mid-secretive phase endometrium in ovulation-normal women.Immunohistochemical analysis was applied to measure the expression of MMP-9/TIMP-1 protein in the implantation window in 15 cases,and MMP-9/TIMP-1 expression in endometrium during different phases were compared.Results:MMP-9/TIMP-1 expression in endometrium was observed in luminal,glandular epithelium and stromal cells in different phases.The expression was lower in proliferative phase,and got to the summit in the implantation window and late secretive phase and it expressed significantly higher in the implantation window phase(P
