Changes of soluble Fas and soluble Fas ligand in infertile patients with endometriosis
- VernacularTitle:子宫内膜异位症不孕与血清和腹腔液中可溶性Fas和可溶性Fas配体的关系
- Author:
Huhua LING
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Infertility;
Fas;
Fas ligand(sFasL)
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the level of soluble Fas antigen(sfas) and soluble Fas ligand(sFasL) and endometriosis associated infertility.Methods:The sfas and sFasL level in sera and peritoneal fluid of infertile women with endometriosis were assessed with enzyme-linked immunosorbent assay,and were compared with those of 14 infertile women resulting from chronic pelvic infectious disease and 16 fertile controls.Results:The sFasL levels(175.09?80.50pg/ml in sera and 284.50?152.38pg/ml in peritoneal fluid) were significantly higher in infertile patients with endometriosis than those of infertile controls(88.47?43.55pg/ml in sera and 17.30?9.62pg/ml in peritoneal fluid) and fertile controls(16.13?11.75pg/ml in sera and 8.84?2.31pg/ml in peritoneal fluid).Compared with the levels of sfas in infertile women resulting from pelvic infectious disease(868.75?570.48pg/ml in sera and 181.76?157.78pg/ml in peritoneal fluid) and fertile control group(822.26?129.12pg/ml in sera and 318.42?145.16pg/ml in peritoneal fluid),the values of sfas in infertile patients with endometriosis(828.60?429.65pg/ml in sera and 349.6?288.89pg/ml in peritoneal fluid) have no significant difference.Conclusion:Endometriosis-related infertility has great association with the level of sFasL,and sFasL may play a key role in the local homeostatic regulation in endometriosis and in turn result in the development of its associated infertility.
