Inhibitory effect of urinary trypsin inhibitor on protease activity in the colonic tissues of ulcerative colitis rats
- VernacularTitle:尿胰蛋白酶抑制剂对鼠溃疡性结肠炎结肠组织中蛋白酶活性的抑制作用
- Author:
Daihua ZHU
- Publication Type:Journal Article
- Keywords:
Urinary trypsin inhibitor;
Ulcerative colitis;
Protease;
Disease model,animal;
Rat
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the effect of urinary trypsin inhibitor(UTI)on protease activity in the colonic tissues of ulcerative colitis(UC) rats.Methods:The experimental UC was induced in Wistar rats by enema with 0.25ml of 18% 2,4-dinitrobenzenesulfonic acid (DNBS) dissolved in ethanol.UTI was injected into the rats through the caudal vein.Protease activity present in colonic tissues was determined on gelatin zymograms.Results:The protease activity which presented in colonic tissues of the group treated with UTI was only 1/3 that of the control.Conclusion:The protease activity decreased significantly after we treated the rats with UTI.
