Protective effect of ascorbic acid on dexamethasone-induced intraocular hypertension in rabbit
- VernacularTitle:抗坏血酸在兔类固醇性高眼压中保护作用的研究
- Author:
Zhaohui LIU
- Publication Type:Journal Article
- Keywords:
Ascorbic acid;
Intraocular pressure;
Dexamethasone;
Trabecular meshwork
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protective effect of ascorbic acid on dexamethasone-induced intraocular hypertension in rabbits.Methods:20 white rabbits were divided into four groups,with 5 in each one group.Every group was treated differently.Their intraocular pressure (IOP) and ascorbic acid concentration of aqueous humors were detected.Their eyeballs were studied for morphologic analysis.Results:There were statistical difference in IOP and ascorbic acid concentration of aqueous humors between the trial group subconjunctivally injected with dexamethasone and control groups.Their histological changes were significantly different.Conclusion:Subconjunctival injection of ascorbic acid can delay and alleviate the dexamethasone-induced intraocular hypertension in rabbits.
