The study of thoracic epidural anesthesia on cardiac function and the size of infarcted area in rabbits with acute myocardial infarction
- VernacularTitle:胸段硬膜外阻滞对急性心肌梗塞兔心功能的影响
- Author:
Jin GAO
- Publication Type:Journal Article
- Keywords:
Epidural anesthesia;
Myocardial infarction;
Hemodynamics;
The size of infarcted area
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
0.1 mv.The rabbits were randomly divided into two groups(n=16):group I was the control;in group Ⅱ, 1% lidocaine 2～3 mg/kg was infused to epidural space.Hemodynamics such as MAP,HR,left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP) and ?dp/dt max were monitored pre- and 30min post-ligation.The extent of infarct area was determined by TTC staining.Results:After ligation,LVEDP increased and LVSP、?dp/dt max decreased in the control group.TEA significantly repressed the increasing of LVEDP and the decreasing of LVSP,?dp/dt max caused by LAD ligation.TEA could reduce the size of infarcted area while there was no significant difference in 4h,8h after ligation.Conclusion:TEA can significantly protect myocardium from injury in rabbits with experimental myocardial infarction.
