Comparision of the efficacy between carvedilol and atenolol in treating chronic congestive heart failure
- VernacularTitle:卡维地洛和阿替洛尔治疗心衰疗效的观察
- Author:
Yongmei HU
- Publication Type:Journal Article
- Keywords:
Carvedilol;
Atenolol;
Heart failure;
Rat
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects between carvedilol and atenolol in treating congestive heart failure of rat models,and to discuss the mechanism of carvedilol.Methods:8 weeks after partial ligating abdominal aorta,30 rats were randomly divided into 3 groups:heart failure group(n=10),carvedilol group(n=10) and atenolol group(n=10).Sham-operated group(n=10) were selected randomly as control.After 4 weeks of medical therapy,hemodynamic parameters and ventricular mass index were studied.Results:Compared with sham-operated group,all the hemodynamic parameters in heart failure group were deteriorated.In carvedilol and atenolol groups,heart rate(HR) and mean blood pressure(MBP) were decreased(P
