The effect of Astragalus membranaceus on serum NO in patients with chronic glomerulonephritis at pre-renal failure phase
- VernacularTitle:黄芪对慢性肾炎非肾衰竭期患者血清NO的影响
- Author:
Xuemei CHEN
- Publication Type:Journal Article
- Keywords:
Chronic glomerulonephrits;
Nitric oxide;
Astragalus membranaceus
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Objective:To observe the effect of Astragalus membranaceus on serum NO in patients with chronic glomerulonephritis at pre-renal failure phase.Methods:The levels of serum NO 3 -/NO 2 - that can indirectly reflect serum nitric oxide were measured in 92 cases of chronic glomerulonephritis (CGN) at pre-renal failure phase and 31 normal subjects by chemical colorimetry.Renal function,serum NO and urinary protein of patients were examined before and after treatment with or without Astragalus membranaceus.Results:1.The levels of serum NO 3 -/NO 2 - in patients were significantly lower than those in the control group,with the lesions of renal function aggravating,the levels of serum NO 3 -/NO 2 - decreasing gradually.2.Astragalus membranaceus could remarkably increase serum NO 3 -/NO 2 - and decrease urinary protein.Conclusion:In patients with chronic glomerulonephritis at pre-renal failure phase,NO is insufficiednt.Astragalus membranaceus may contribute to the synthesis of NO and the decrease in urinary protein excretion.
