Perfusion of pulmonary artery with hypothermic protective solution reduces the inflammatory response of lung during cardiopulmonary bypass
- VernacularTitle:肺动脉灌注低温保护液减轻体外循环肺内炎性反应
- Author:
Bo WEI
;
Yinglong LIU
;
Cuntao YU
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass Inflammation Perfusion, regional
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effect of perfusion of pulmonary artery using hypothermic protective solution on the inflammatory response of lung during cardiopulmonary bypass. Methods: 40 children with TOF were divided into control group (n=20) and protective group (n=20). The basic parameters (age, weight, C/T ratio, oxygen saturate) were not different between both groups. In control group, the operation was performed using routine approaches. While in protective group pulmonary artery were infused with 4℃ protective solution during CPB. Plasma TNF-?, IL-6 and IL-8 of tracheal suction was measured. Lung biopsy specimens were obtained after operations for study on histological changes. At same time, patients' pulmonary functions and clinic index were monitored. Results: TNF-? was lower in protective group when compared with control group immediately and at 24h after operations (P
