Effects of ulinastatin on lung function after cardiopulmonary bypass
- VernacularTitle:乌司他丁对体外循环心脏手术后肺功能的影响
- Author:
Kangqing XU
;
Peiwu SUN
;
Wenqi HUANG
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass Respiratory function test Reperfusion injury Ulinastatin
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effects of ulinastatin (UTI) on lung function after cardiopulmonary bypass. Methods: 60 patients, ASA score II～III, scheduled for elective cardiac valvular replacement, were randomly allocated into three groups. Study group (group I, n=20), UTI 10?000 U/kg group (group II, n=20), and UTI 20?000 U/kg group (group III, n=20). OI, V_D/V_T, P(A-a)O_2, CaO_2 , SaO_2 and PaO_2 were studied respectively. Ventilation time, simultaneous breath frequency within 24 hours after extubation and respiratory changes were also observed. Results: Compared with pre-CPB, in group I, postoperative OI, V_D/V_T, P_ (A-a) O_2 increased and CaO_2, SaO_2, PaO_2 decreased, respectively (P
