Effect of losartan on urinary albumin excretion in experimental diabetic rats
- VernacularTitle:氯沙坦对实验性糖尿病大鼠尿白蛋白排泄的影响
- Author:
Dongmei ZHANG
;
Huiju ZHONG
;
Min ZHOU
- Publication Type:Journal Article
- Keywords:
Losartan Diabetic rat Urinary albumin
- From:
Chinese Journal of Diabetes
2000;8(6):360-361,359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of losartan on urinary albumin excretion in streptozotocin diabetic rats.Methods The following groups of rats were studied:normal control rats(NC),diabetic control rats (DC),diabetic rats treated with losartan 〔20mg/(kg*d)〕(DL) and diabetic rats treated with perindopril （2mg/(kg*d)〕(DP).Urinary albumin was observed at the 4th、8th、12th and 16th week.Results Urinary albumin excretion of diabetic rats treated with losartan or perindopril were significantly lower than that of diabetic untreated group (P＜0.01).The effect was not different between losartan treated and perindopril treated rats.Conclusion The results suggested that losartan can reduce urinary albumin excretion in diabetic rats.
